The Clinical Value of Soluble Cytokeratin-18 in Differentiating Simple Steatosis from Non Alcoholic Steatohepatitis

Serum cytokeratin-18 in the diagnosis of non-alcoholic steatohepatitis: A meta-analysis.

AIM Identifying patients with non-alcoholic steatohepatitis (NASH), a more aggressive form with a worse prognosis than for simple steatosis, is highly important. Liver biopsy still remains the gold standard for diagnosing NASH, but with limitations. The diagnostic value of serum cytokeratin-18 (CK-18) in predicting NASH is still indefinite. METHODS We selected relevant studies by a literature...

Non-Alcoholic Steatohepatitis: Pathogenesis and Clinical Management

1Division of Gastroenterology, Ospedale di Acireale, Azienda Sanitaria Provinciale di Catania, Catania, Italy 2Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel 3School of Public Health, University of Haifa, Haifa, Israel 4Department of Biomedical Sciences and Biotechnologies, University of Catania, Catania, Italy 5Center for Human Nutrition and Atkins Center...

Non-Alcoholic Steatohepatitis: Clinical and Translational Research.

UNLABELLED The present review includes translational and clinical research that characterize non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Clinical and experimental evidence led to the recognition of the key toxic role played by lipotoxicity in the pathogenesis of NAFLD. The current understanding of lipotoxicity suggests that organ injury is initiated by th...

Silymarin in treatment of non-alcoholic steatohepatitis: A randomized clinical trial

Abstract Background: No pharmacologic agents have been approved for the treatment of non-alcoholic steatohepatitis (NASH) that is common in our region. The present study was designed to evaluate the efficacy of silymarin, a known herbal drug, in the treatment of NASH. Methods: This clinical-trial study was conducted on 64 patients with NASH who were randomly divided as case group (33) and con...

Non-alcoholic steatohepatitis